Iannis Talianidis
Research Director, AXA Chair in Epigenetics
The main research interest of our group is to study the molecular mechanisms governing the transcriptional regulation of liver-specific genes. Our research is broadly centered around the analysis of the function of hepatic regulators and the general transcription machinery. We use biochemical, genetic and cell biology approaches to study the chromatin organization and the regulated assembly of the transcription machinery on hepatic genes involved in the regulation of various metabolic pathways and/or hepatocyte differentiation. Focus is on studies of epigenetic mechanisms with an ultimate goal to describe the complete Epigenomes matching the hepatocyte cell type at different stages of liver development and during hepatocarcinogenesis.