DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation

[Nature Aging]

ALBUMIN: The most abundant human blood protein acts as a shield against deadly fungal infections

[Nature] [Press Release]

A novel carboxylesterase drives insecticide cross resistance in the malaria mosquito

[Nature Communications] [Press Release]

For the love of frontier research, or why Elon’s rockets keep blowing up

Phase separation meets energy generation to boost longevity

Dendritic plasticity links memories across time

[Nature Neuroscience]

Artificial neural networks with dendrites: a possible solution for modern, energy-hungry, AI systems

[Nature Communications] [Press Release]

Activity-dependent K+ hotspots selectively boost the dendritic excitability of neurons, acting as 'volume knobs'

Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans

Seed longevity is controlled by metacaspases

[Press Release] [Nature Communications]

Spermidine is vital for inducing autophagy and extending longevity during intermittent fasting

Endonucleosis mediates internalization of cytoplasm into the nucleus

Nature Communications PubMed

Reproductive status regulates the mitochondrial stress response

Cell Reports PubMed

Cancer associated fibroblasts form immune synapses with T regulatory cells, promoting tumor expansion

[PubMed]

Transcription stress leads to paracrine senescence

DNA damage in microglia leads to neurodegeneration

[PNAS]

Polycomb-mediated silencing of miR-8 is required for maintenance of intestinal stemness in Drosophila melanogaster

[Nature Communications]

Detection of isothermally-amplified DNA by naked-eye observation

[Analytical Chemistry]

Modeling apical and basal tree contribution to orientation selectivity in a mouse L2/3 V1 pyramidal cell

[eLife]

RNA interference and maintenance of heterochromatin in a marine phytoplankton

[New Phytologist]

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes

[Science Advances]

Profiling the dynamics of chromatin release of newly transcribed RNA

[Cell Systems]

Caloric restriction mimetic enhances remyelination by promoting a less inflammatory environment

[PubMed]

A transporter in mosquito legs acts like a pump, exporting insecticide out of the organism

[PLOS]

A study of brain tumor progression in a Drosophila model

[Press Release] [PNAS]

Unlocking the Potential of PML: A Defender Against Breast Cancer Metastasis

[Molecular Oncology]

Balanced mRNA storage and degradation modulates mitochondrial biogenesis, ageing and stress responses

[EMBO Journal]

Remote control of autophagy and metabolism in the liver

[Cell Metabolism]

Revealing the structure and function of a cytoskeletal actin in malaria parasites

[Plos Pathogens]

Impaired glucose metabolism and liver-α-cell axis in mice with ablation of the HNF4A gene in the liver

[PubMed]

ΙΜΒΒ scientists uncovered the molecular mechanisms involved in the pathogenesis of the neurodegenerative disorder Wolfram Syndrome

[Nature CDDis]

Discovering a disinhibitory microcircuit responsible for contextual information processing in the hippocampus

[Cell Reports]

Age-dependent nuclear lipid droplet accumulation is a cellular hallmark of ageing

[Aging Cell]

An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life

[Nature Communications]

IMBB-FORTH scientists uncovered a novel cellular mechanism that regulates ageing and fertility

[Nature Aging]

Deregulation of the 3D-genome structure of T cells causes autoimmunity

[PubMed] [Nature]

DNA damage responses drive the autoreactivity of B cells

[PubMed]

Pathogenic bacteria inhibit host cell secretion to manipulate host immunity

[Plant Cell]

Reduction of mitochondrial mass extends lifespan and protects against glucotoxicity

Structural dynamics in the evolution of a bilobed protein scaffold

[PNAS]

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage

[Pubmed]

IL-33-decorated neutrophil extracellular traps promote IFNα production in SLE

[JCI Insight]

Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

[Pubmed]

Uncoupling IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis

[Pubmed]

Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine learning-based model to assist the diagnosis of systemic lupus erythematosus

[Pubmed]

The splicing factor XAB2 interacts with ERCC1-XPF and XPG for loop processing

[Pubmed]

Reduced proinsecticide activation by cytochrome P450 confers coumaphos resistance in the major bee parasite Varroa destructor

[Pubmed]

Dissecting Hes-centred transcriptional networks in neural stem cell maintenance and tumorigenesis in Drosophila

[Pubmed] [Journal]

Regionalized tissue fluidization is required for epithelial gap closure during insect gastrulation

[Pubmed] [Nature Communications]

Neural Stem Cell Delivery via Porous Collagen Scaffolds Promotes Neuronal Differentiation and Locomotion Recovery in Spinal Cord Injury

[Pubmed]

Breakdown of spatial coding and interneuron synchronization in epileptic mice

[Pubmed]

Tissue-infiltrating macrophages mediate exosome-based metabolic reprogramming upon DNA damage

[Pubmed]

Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons

[Pubmed]

Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators

[Pubmed]

Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans

[Pubmed]

Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity

[Pubmed]

The Role of Insulators in Transgene Transvection in Drosophila

[Pubmed]

In a collaborative work IMBB and Columbia University researchers revealed how VIP interneurons in the hippocampus regulate spatial learning

[Pubmed]

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

[Pubmed]

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

[Pubmed]

Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species

[Pubmed]

Calcium sequestration by fungal melanin inhibits calcium-calmodulin signaling to prevent LC3-associated phagocytosis

[Pubmed]

Aspirin Recapitulates Features of Caloric Restriction

[Pubmed]

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

[Pubmed] [F1000]

Regulation of brain autophagy by BDNF signaling and nutritional stress

[Pubmed]

Novel functions of DNA repair proteins during mammalian development

[Pubmed]

Controlling longevity by coordinating mitochondrial biogenesis and turnover during ageing

[Pubmed]

Long noncoding RNAs regulate allelic gene expression

From amputation to regeneration – researchers identify shared features of limb regeneration in crustaceans and vertebrates

TPL2 kinase is a suppressor of lung carcinogenesis

Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis

A segmentation clock with two-segment periodicity in insects.

bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized

Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions

Quaternary Dynamics of the SecA Motor Drive Translocase Catalysis

Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans

A versatile strategy for gene trapping and trap conversion in emerging model organisms

Small heat-shock proteins protect from heat-stroke-associated neurodegeneration

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

The role of VEGF Signaling and UPR in Angiogenesis